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However, the disadvantages include invasiveness, longer recovery times, and high costs, similar to most major surgical procedures

Semaglutide directly accessed the brainstem, septal nucleus, and hypothalamus but did not cross the blood-brain barrier

The most common typically strongest in the first 48 weeks as the body adapts include: Nausea (most common, usually dose-dependent) Diarrhoea or constipation Fatigue , especially during dose escalations Mild headache Reflux and acid reflux Loss of appetite (this is the therapeutic effect, not a side effect, but it can be uncomfortable) Less common but more serious effects warranting immediate physician review include pancreatitis, gallbladder disease, and kidney issues, particularly in patients with pre-existing conditions

An imbalance in these electrolytes can trigger muscle cramps, especially in the legs

They also check heart health, digestion, pregnancy plans, and current prescriptions

Vision changes, severe headaches, or confusion may signal other serious reactions