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LEADER [29] and SUSTAIN-6 [30] reported a prespecified renal composite of new onset or persistent macroalbuminuria, persistent doubling of serum creatinine and eGFR 45 mL/min/1.73 m 2 , need for renal replacement therapy (RRT), and renal death

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In the case of most healthy adults, there is no need to worry because the oral glutathione used daily in the long term should not have any harm provided it is not exceeded

Throughout the manuscript, we critically evaluate the hierarchy and reliability of the evidence by specifically emphasizing methodological limitations, study design flaws, the presence or absence of placebo controls, and baseline population equality

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GLP-1R agonists The GLP-1R agonists mediate their action by acting directly on the GLP-1R