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Harmful hydrogen peroxide cellular levels are minimized by the enzyme glutathione peroxidase (GP) using GSH as a reductant
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These strategies achieve active manipulation of ROS generation pathways by directionally amplifying oxidative pressure in lesion areas
Kim H, Yi N, Do BR, Lee AY
In particular, L-glutamate and L-cysteine metabolism play key roles in glutathione synthesis and metabolism, and the -glutamyl cycle ensures the recycling of cysteine/glutamate and so the maintenance of the glutathione pool
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