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Conversely, the increased export of 2-Oxoglutarate into the cytosol could augment the activity of Fe (II) 2-oxoglutarate (2OG)dependent oxygenases, enzymes that catalyze a variety of critical reactions including hydroxylation, halogenation, desaturation, and ring transformation

Synovial tissue hypoxia and inflammation in vivo

Aimin Meng, G

Important caveat: there are no completed controlled human clinical trials of injectable or systemic GHK-Cu