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Fernandez-Millan E, Martin MA, Goya L, Lizarraga-Mollinedo E, Escriva F, Ramos S, et al

Hyperglycemia enhances platelet activation and high-shear stressinduced activation, leading to arterial thrombosis, partly due to acute enhancement of the circulating levels of von Willebrand factor (Stegenga et al., 2006), nonenzymatic glycation of platelet glycoproteins, changes in their conformation and membrane lipid structure alterations ( On the other hand, hypoglycemia, which is the main adverse effect of insulin therapy, also appears to be associated with platelet activation

Factors to consider include timing of rash to drug exposure, rash distribution and clinical appearance, and the presence of systemic features such as mucosal involvement, organ failure, or eosinophilia

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