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This is the theoretical basis for endogenously supplied gamma-glutamylcysteines ability to raise GSH levels, as being the product of the GCL enzyme, it can be taken up by cells intact, where it feeds directly into glutathione synthase to be converted to glutathione, effectively bypassing the dysfunctional GCL

Once confined primarily to academic laboratories, bioactive peptides are now widely examined for their potential roles in tissue regeneration, metabolic regulation, and cellular signaling

Dosing should be individualized based on patient response and laboratory markers

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Mari et al., 2009), which in the liver account for about one third of the total Gpx activity ( 2 O 2 and has been classically believed to be the major H 2 O 2 reducing enzyme

histologically, they appear as distended, weakly-staining cells with large, realtively clear nuclei) and brain edema were described and evaluated semiquantitatively (22)