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In contrast, CCB monotherapy, ACE inhibitor plus CCB, and -blocker plus thiazide diuretic were associated with significantly higher rates of treatment discontinuation

The within-group Cohens d effect size for improvement (difference between the mean of screening, first and second baseline, and posttreatment) was large ( d = 1.46

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Oxidative stress in depression: the link with the stress response, neuroinflammation, serotonin, neurogenesis and synaptic plasticity