Consistent with a protective role of redox control, overexpression of glutaredoxin (GLRX, also known as GRX1) attenuates FAS SSG and partially protects against FAS-dependent apoptosis
734,735 Senescent cells are characterized by cell cycle arrest, increased autophagy, and heightened apoptosis, along with markers such as p21 and the senescence-associated secretory phenotype (SASP)
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A wide range of non-motor manifestations, including hyposmia or anosmia, gastrointestinal disturbances like chronic constipation, rapid eye movement (REM) sleep behavior disorder, autonomic dysfunction, mood changes like depression and anxiety, and progressive cognitive impairment, account for a significant portion of the disease burden [3]
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The specialists at COEM provide personalized guidance to help patients decide whether this therapy aligns with their treatment goals and health needs