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DOI: 10.1093/oxfordjournals.humrep.a137950 115

Age-dependent declines were detected both in hippocampal volume and cortical thickness (Fig

R.DiniL.BalestraE.DagostiniC.et al (1995)

& Klionsky, D

For example, NAD+-dependent enzymes include the sirtuins (SIRT1-7), a family of protein deacetylases involved in gene expression, stress responses, and metabolic regulation, as well as poly(ADP-ribose) polymerases (PARPs) that assist in DNA repair