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Its proposed mechanisms include modulation of ACTH release, antioxidant activity, and opioid system interaction, but most human evidence is weak or dated

10.1016/j.molmed.2014.01.005 Trends Mol

Diabetes Obes Metab 28, 112121 (2026)

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In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)